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Cortistatin A

CAS No. 882976-95-6

Cortistatin A ( +)-cortistatin A )

Catalog No. M16400 CAS No. 882976-95-6

A potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cortistatin A
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19.
  • Description
    A potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19; does not inhibit other transcriptional CDKs CDK7 (TFIIH), CDK9 (P-TEFb), CDK12, or CDK13 in vitro, and no activity against CDK9, CDK12, CDK13, ROCK1 or ROCK2 in MOLM-14 cell lysate (>2.5 uM), also binds to ROCK1 and ROCK2; demonstrates antileukaemic activity by inhibiting Mediator kinases in vitro and in vivo.
  • Synonyms
    +)-cortistatin A
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    882976-95-6
  • Formula Weight
    472.63
  • Molecular Formula
    C30H36N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@@]12[C@@H](C3=CC4=C(C=C3)C=CN=C4)CC[C@@]1([H])[C@@]56CC[C@@]7(O6)C[C@H](N(C)C)[C@@H](O)[C@H](O)C7=CC5=CC2
  • Chemical Name
    (3S,3aR,7R,8R,9S,10aR,12aS,12bR)-9-(Dimethylamino)-1,2,3,3a,4,7,8,9,10,11,12,12b-dodecahydro-3-(7-isoquinolinyl)-3a-methyl-10a,12a-epoxybenzo[4,5]cyclohept[1,2-e]indene-7,8-diol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.
2. Cee VJ, et al. Angew Chem Int Ed Engl. 2009;48(47):8952-7.
3. Poss ZC, et al. Cell Rep. 2016 Apr 12;15(2):436-50.
4. Pelish HE, et al. Nature. 2015 Oct 8;526(7572):273-276.
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