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Cortistatin A
CAS No. 882976-95-6
Cortistatin A( +)-cortistatin A )
Catalog No. M16400 CAS No. 882976-95-6
A potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product NameCortistatin A
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19.
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DescriptionA potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19; does not inhibit other transcriptional CDKs CDK7 (TFIIH), CDK9 (P-TEFb), CDK12, or CDK13 in vitro, and no activity against CDK9, CDK12, CDK13, ROCK1 or ROCK2 in MOLM-14 cell lysate (>2.5 uM), also binds to ROCK1 and ROCK2; demonstrates antileukaemic activity by inhibiting Mediator kinases in vitro and in vivo.
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In Vitro——
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In Vivo——
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Synonyms+)-cortistatin A
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number882976-95-6
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Formula Weight472.629
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Molecular FormulaC30H36N2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@]12[C@@H](C3=CC4=C(C=C3)C=CN=C4)CC[C@@]1([H])[C@@]56CC[C@@]7(O6)C[C@H](N(C)C)[C@@H](O)[C@H](O)C7=CC5=CC2
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Chemical Name(3S,3aR,7R,8R,9S,10aR,12aS,12bR)-9-(Dimethylamino)-1,2,3,3a,4,7,8,9,10,11,12,12b-dodecahydro-3-(7-isoquinolinyl)-3a-methyl-10a,12a-epoxybenzo[4,5]cyclohept[1,2-e]indene-7,8-diol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johannessen L, et al. Nat Chem Biol. 2017 Oct;13(10):1102-1108.
2. Cee VJ, et al. Angew Chem Int Ed Engl. 2009;48(47):8952-7.
3. Poss ZC, et al. Cell Rep. 2016 Apr 12;15(2):436-50.
4. Pelish HE, et al. Nature. 2015 Oct 8;526(7572):273-276.
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